RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-155
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Oxysterol assay etc.
Target
Lxra
Pathway
NA
PubMed ID
Title
The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis
Year
2016
Function
"MiR-155-/- mice developed exacerbated lung fibrosis, increased collagen deposition, collagen 1 and 3 mRNA expression, TGF-B production, and activation of alternatively activated macrophages, contributed by deregulation of the miR-155 target gene the liver X receptor (LXR)a in lung fibroblasts and macrophages.LXRa can increase the expression of Arginase 2, TGF-B, promote collagen production and IPF progression."